Cancer vaccines have shown clinical promise in driving tumor-reactive cell activation, proliferation, and effector functions. Cancer vaccine therapy, on the other hand, has not been successful in eradicating tumors and has limited efficacy in some patients. …

In preclinical models of SCLC, CD47 blockade was found to be effective in enhancing the local antitumor effects of radiotherapy. “Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect,” a related study, was published in Nature Cancer. …

Acute myeloid leukemia (AML) is a clonal malignant proliferative disease of the hematopoietic system’s myeloid primitive cells that is highly heterogeneous, usually incurable with chemotherapy, has a poor prognosis, and is prone to relapse. …

The current diagnostic criteria for SSD place a greater emphasis on patient behavior assessment and frequently involve patient self-assessment, which is very subjective and not helpful for early diagnosis or efficacy evaluation. The scientific reliability of SSD diagnosis will be significantly increased if optimal biomarkers for SSD can be discovered. …

Cancer immunotherapy has shown great promise in cancer treatment over the last decade. Several cancer immunotherapies, such as immune checkpoint blockade therapies, cancer vaccines, and CAR-T therapies, have been extensively researched and have yielded promising results. Cancer vaccines, which elicit tumor-specific immune stimulation, are one of the most important immunotherapeutic…

Recently, Sean M. Hartig’s team from Baylor College of Medicine published an article in Cell Metabolism titled “The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice”. They found that the FDA-approved rheumatoid arthritis drug Auranofin accumulates in white adipose tissue, improves insulin sensitivity, and…

Pancreatic cancer is a highly malignant tumor of the digestive system, and traditional clinical treatments such as surgery and chemotherapy are very limited in terms of prolonging the survival cycle of pancreatic cancer patients and increasing toxic reactions to drugs. …

While traditional vaccines are dedicated to the prevention of a wide range of infectious diseases, cancer vaccines, which have received much attention in recent years, aim to focus the power of the body’s immune system on the elimination of tumor cells. Although existing immunotherapies (e.g., immune checkpoint inhibitors and chimeric…

Cholesterol, an essential component for building cells, is also a “prime suspect” for cardiovascular disease (CVD) — high levels of cholesterol in the blood are an important risk factor for CVD. There are three main types of hypolipidemic drugs on the market today — statins, ezetimibe, and PCSK9 inhibitors. …